This session will be the first in a series of virtual scientific webinars exploring the diverse considerations for heavily treatment-experienced (HTE) patients with multidrug resistance (MDR). The first webinar in the series will serve as a brief introduction to HTE patients; virology; pharmacology; and treatment options. The following webinars; running throughout 2022; will address specific questions about the treatment of this important population of HIV patients; including case-based discussions and supporting data.